The basic function of the cutaneous desmosome is to assure the epidermal integrity by attaching the cytoskeleton of a cell to the cytoskeleton of the adjacent cell. Desmosomes are also important because they play a role in epithelial morphogenesis and differentiation. Moreover, the proteins of desmosomes are major antigens in autoimmune skin disorders, such as pemphigus. Pemphigus is characterized by the separation of skin cells, causing burn-like lesions and blisters.