The presence of a nucleus in amphibian red blood cells allows researchers easy access to large quantities of amphibian DNA. Frog blood has both a solid and a liquid portion. The liquid plasma carries solid elements such as red and white blood cells. Blood can be collected from frogs and the red blood cells isolated by centrifugation. After removal of the residual plasma, purified cells can be treated with specific enzymes and detergents to digest the cellular envelope and release DNA from its protein complex. The DNA is then useful for scientific studies and experiments.