Altering the Threshold of an Excitable Signal Transduction Network Changes Cell Migratory Modes

Research appearing in Nature Cell Biology shows that different cell migratory modes arise from varying threshold levels for the excitation of related signal transduction pathways. Change in cell migratory mode is an important aspect of metastasis.

TIRF imaging of signal transduction and the cytoskeleton was performed using a Nikon Ti-E inverted microscope.

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