Developmental Alterations in Huntington's Disease Neural Cells and Pharmacological Rescue in Cells and Mice
March 22, 2017, via Nature Neuroscience
New research in Nature Neuroscience examines the mechanisms underlying neurodegeneration due to Huntington’s disease. Patient-derived induced pluripotent stem cells were used to create neural models of the disease, and RNA-seq applied towards identification of genes with decreased expression. Treatment targeting key dysregulated pathways is demonstrated in mice models. Automated robotic microscopy of iPSC cultures was performed using a Nikon Ti inverted microscope with Perfect Focus.