Gephyrin-binding Peptides Visualize Postsynaptic Sites and Modulate Neurotransmission
November 30, 2016, via Nature Chemical Biology
Researchers have developed fluorescent cell-permeable “super-binding” peptides for specific labeling of gephyrin - a marker of the inhibitory postsynaptic density - demonstrating conventional and super-resolution imaging of inhibitory postsynaptic sites for the first time. These peptides also act as modulators of inhibitory neurotransmission. The authors hope to expand the desigin and use of fluorescent “super-binding” peptides to other cellular targets.