New research in Cell finds that the rate of synthesis for leading and lagging strand DNA polymerases are uncoordinated and can vary up to 10-fold. Furthermore, when DNA polymerase activity is paused, the rate of DNA unwinding by helicase drops by ~80% to allow for recoupling. Imaging was performed using a Nikon TE2000-U with 100x (NA 1.49) TIRF objective.