RNA Phase Transitions in Repeat Expansion Disorders
June 06, 2017, via Nature
New research in Nature shows that nucleotide repeat expansion disorders, such as ALS, require a certain number of repeats before transcripts form foci in the nucleus, with in vitro experiments showing that multivalent base-paring can lead to gelation of RNA.
Imaging was performed using a Nikon Ti-E inverted research microscope with Yokogawa X1 spinning disk.