Normal African Green Monkey Kidney Fibroblast Cells (CV-1 Line)
The CV-1 cell line was initiated in March of 1964 with a tissue section excised from the kidney of an adult male African green monkey (Cercopithecus aethiops). The fibroblast line was originally utilized in research focusing on the transformation of the cancer-causing Rous sarcoma virus (RSV), but now is popular as a host for acquired immunodeficiency disease (AIDS) research, as well as transfection experiments with simian virus 40 (SV40) and recombinant plasmid vectors. CV-1 cells exhibit fibroblast morphology, grow adherently to glass or plastic surfaces, and are negative for reverse transcriptase. The cells are known to be susceptible to several viruses, including poliovirus 1, herpes simplex, simian virus 40, California encephalitis, and both Eastern and Western equine encephalitis. The cells exhibit rapid growth and chromosome number shifts have been reported to occur at high passage levels.