CALI Literature References

Specialized fluorescent proteins are emerging as useful reagents for chromophore-assisted light inactivation (CALI) due to their ability to selectively target specific proteins. In CALI, a photosensitizer chromophore is attached to a target protein, usually through genetically-encoded fusion mechanisms. Illumination of the chromophore generates reactive oxygen species (ROS), which are potent protein inactivators that are sufficiently short-lived as to inactivate only the target protein, thus limiting damage to surrounding molecules.

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Chromophore-Assisted Light Inactivation