Photoactivated Localization Microscopy (PALM) Literature References

Similar in concept to STORM, photoactivated localization microscopy utilizes optical highlighter fluorescent proteins to stochastically switch on a sub-population of molecules for sequential single-molecule readout. The fundamental principle behind PALM and related methodology is that the activated state of a photoswitchable molecule must lead to the consecutive emission of sufficient photons to enable precise localization before it enters a dark state or becomes deactivated by photobleaching.

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PALM Microscopy