Stochastic Optical Reconstruction Microscopy (STORM) Literature References

Stochastic optical reconstruction microscopy (STORM) relies on the sequential and stochastic readout with precise localization of multiple single molecules from specimens that were fluorescently labeled with photoswitchable dyes at densities approaching those commonly employed in widefield and confocal fluorescence microscopy (ranging up to 100,000 molecules per square micrometer). STORM utilizes an activation laser applied at low power to trigger emission switching so that any particular molecule has a small probability of being photoactivated, but the majority of the population remains in the original (dark or native) emissive state.

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STORM Microscopy