Superresolution Microscopy Review Articles

Over the past several years, a number of novel single-molecule and more complex instrument-based approaches have been employed to circumvent the diffraction limit, including photoactivated localization microscopy (PALM), stochastic optical reconstruction microscopy (STORM), near-field scanning optical microscopy (NSOM), stimulated emission depletion microscopy (STED), saturated structured-illumination microscopy (SSIM), and ground state depletion (GSD) microscopy. In addition, numerous other approaches have been used to achieve better resolution than can be obtained with traditional optical microscopy imaging methodology. These techniques have all achieved improved lateral (x-y) resolution down to tens of nanometers, more than an order of magnitude beneath that imposed by the diffraction limit, but each method has a unique set of limitations.

Recommended Literature

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Additional Literature Sources

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