RNA Polymerase II Clustering Through Carboxy-Terminal Domain Phase Separation
August 21, 2018, via Nature Structural & Molecular Biology
RNA Polymerase II (Pol II) is important for transcription of DNA, but how does it get there? Researchers have found that Pol II can reversibly phase separate into liquid droplets and form “hubs” at active genes.
Single molecule imaging for this study was performed on a Nikon TIRF microscope.
