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How ‘magic angle’ graphene is stirring up physics

Have you heard about the newly discovered graphene ‘magic angle’? Overlaying a pair of graphene sheets with their relative rotation set to the ‘magic angle’ results in unexpected superconductivity. There is also the possibility that this mechanism may be similar to those governing high-temperature superconductors.

Learn More @ Nature

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells

Researchers have succeeded in the direct reprogramming of human somatic cells into induced neural plate border stem cells (iNPBSCs) via ectopic expression of 4 factors. The iNPBSCs are self-renewing, multipotent, and easily modified with CRISPR/Cas9, with potential for applications in regenerative medicine.

Learn More @ Cell Stem Cell

3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds

The Boyden lab at MIT does it again with new Implosion Fabrication (ImpFab). Like Expansion Microscopy, ImpFab also exploits the shrinking/swelling properties of hydrogels to manipulate object size. ImpFab uses a hydrogel scaffold for arranging structures while at an easily workable size, followed by dehydration of the gel to shrink the entire assembly to a nano size. Importantly, this allows for new geometries that can’t be made through the typical process of assembly by stacking layers.

Learn More @ Science

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Alpha-catenin is a key protein linking the actin cytoskeleton with intercellular adhesions. Researchers at the University of Toronto shine new light on the mechanisms of tension-dependent F-actin binding by alpha-catenin.

Scratch wound assays for this study were performed using a Nikon IM-Q incubated microscope, and confocal imaging in part with a Nikon A1R resonant scanning system.

Learn More @ Nature Communications

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

Osteoarthritis doesn't currently have any disease-modifying treatments, but researchers have just published a new #dendrimer based carrier for delivering IGF-1 to joint cartilage chondrocytes, reducing cartilage degeneration in rat knees. Confocal imaging of cartilage explant sections for this study was performed using a Nikon A1R microscope.

Learn More @ Science Translational Medicine

Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-targeting agents (MTAs) such as paclitaxel are important chemotherapy drugs used to disrupt cell migration. University of Minnesota researchers provide a new theoretical basis for the role of microtubules and MTAs in cell migration control.

Microtubule tracking and FRAP experiments for this study were performed with a Nikon Ti-E inverted microscope.

Learn More @ Cell Reports

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