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Iterative Expansion Microscopy

Check out new iterative Expansion Microscopy published in Nature Methods. Samples are physically magnified ~20x, compared to previous factor of ~4.5x. This new method is validated for visualization of synaptic proteins and the structure of dendritic spines. Imaging was performed using a Nikon Ti-E inverted microscope with 40x 1.15 NA water immersion objective.

Learn More @ Nature Methods

Anchored But Not Internalized: Shape Dependent Endocytosis of Nanodiamond

New research in Scientific Reports examines how morphology affects the endocytosis of nanoparticles, a critical step for applications ranging from intracellular sensing to drug delivery. They found that round nanodiamond is endocytosed to a greater degree than “prickly”-shaped nanodiamond. Super-resolution imaging was performed using a Nikon N-SIM structured illumination system.

Learn More @ Nature Scientific Reports

Allen Cell Explorer

Check out the newly released Allen Cell Explorer, a library of thousands of induced pluripotent #stemcell images created by the Allen Institute for Cell Science. Future plans include the application of machine learning to predict the position and morphology of cell components based off other markers.

Learn More @ Allen Cell Explorer

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

New open access research in Stem Cell Reports utilized induced pluripotent stem (iPSC) models of amyotrophic lateral sclerosis to identify pathways dysregulated by mutant SOD1 in human motor neurons, finding that ERK and JNK signaling are key in neurodegeneration. Electrophysiology experiments were performed on a Nikon Ti-E inverted microscope.

Learn More @ Cell

The Lung is a Site of Platelet Biogenesis and a Reservoir for Haematopoietic Progenitors

Researchers at UCSF have provided the first direct evidence for substantial platelet biogenesis in the lungs in a new article published in Nature. A Nikon A1R MP multiphoton microscope was used to visualize lung microcirculation in mice, showing large numbers of megakaryocytes dynamically releasing platelets. Approximately half of platelet production was found to occur in the lungs in their model.

Learn More @ Nature

Nikon is Looking for a Bioscience Consignment & Trade Show Administrator

If you’re looking to join a company with a dynamic vision for the future, set your sights on a challenging career with Nikon. Nikon USA is currently looking for a Bioscience Consignment & Trade Show Administrator! Key responsibilities of this position include coordinating equipment for tradeshows, workshops, and more. This is a great opportunity for non-specialists with strong organizational skills and who are available to travel to learn about optical microscopy and the medical device industry. To learn more and apply click below!

Learn More @ Nikon Instruments

Developmental Alterations in Huntington's Disease Neural Cells and Pharmacological Rescue in Cells and Mice

New research in Nature Neuroscience examines the mechanisms underlying neurodegeneration due to Huntington’s disease. Patient-derived induced pluripotent stem cells were used to create neural models of the disease, and RNA-seq applied towards identification of genes with decreased expression. Treatment targeting key dysregulated pathways is demonstrated in mice models. Automated robotic microscopy of iPSC cultures was performed using a Nikon Ti inverted microscope with Perfect Focus.

Learn More @ Nature Neuroscience

2017 Focus On Microscopy

The 2017 Focus On Microscopy conferences are fast approaching! Come find us at Booth 4/5/6/7 and Lecture Room H1/H2 from April 9-12 at the Palais Des Congrès in Bordeaux, France.

We will be holding workshops on imaging with the new Ti2, correlative confocal and SIM imaging, and enhanced confocal imaging. To sign up, please contact us at instruments-info.eu@nikon.com.

Learn More @ Nikon Instruments

Lung Vaso-occlusion in Sickle Cell Disease Mediated by Arteriolar Neutrophil-platelet Microemboli

Researchers at University of Pittsburgh have demonstrated the therapeutic potential of targeting platelet adhesion molecules in reducing the formation of neutrophil-platelet aggregates, which form microemboli in patients with sickle cell disease. Intravital imaging was performed with a Nikon A1R MP multiphoton system and super-resolution SIM using a Nikon N-SIM system. Check out the open-access article in Journal of Clinical Investigation to learn more.

Learn More @ JCI Insight

First Fluorescent Frog Found

The first fluorescent frog has been found! The polka dot tree frog fluoresces blue and green upon excitation by UV light. Researchers are now considering the evolutionary function of fluorescence in this, and perhaps other, frog species.

Learn More @ Nature

The Quest to Crystallize Time

A “time crystal” may sound like a sci-fi/fantasy MacGuffin, but they’re real, and they’re weird…
Where normal crystals exhibit 3D spatial symmetry, time crystal structure is also symmetrical in time. Check out this Nature News and Comment article to learn about the recent creation of time crystals and their implications.

Learn More @ Nature

Super-Resolution and Confocal Seminar

Please join us tomorrow, March 7th for a seminar on Super-Resolution and Confocal Microscopy at the UTHealth Science Center. The seminar will be held in MSB 2.103 from 10:30AM – 12:00PM.

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength

New research in Biophysical Journal identifies differences in Mg2+ and Ca2+ mediated cell adhesion strength between metastatic and non-metastatic cells. Adhesion strength in metastatic cells is more sensitive to Mg2+ and Ca2+ mediated focal adhesion disassembly, whereas non-metastatic cell adhesion is insensitive to these ions. Imaging was performed using a Nikon Ti-S inverted microscope.

Learn More @ Biophysical Journal

Focus On Microscopy Conferences

This year’s Focus On Microscopy conferences (FOM) will be held 9-12 April at the Bordeaux Congress Centre in Bordeaux, France. Come find Nikon at Booth 4/5/6/7 and make sure to check out the newly released Ti2 inverted microscope, featuring an unprecedented 25 mm Field of View! Nikon will also be holding a series of workshops.

FOM is a series of meetings on advanced light microscopy techniques; this year’s topics include confocal, multiphoton, super-resolution, and more.

Learn More @ Nikon Instruments

A Giant Neuron Found Wrapped Around Entire Mouse Brain

Check out this news article in Nature about a new imaging method used to identify a single neuron encircling an entire mouse brain. Researchers believe this technique might help elucidate the mechanisms of consciousness. GFP was used to selectively mark a small number of claustrum neurons, 10,000 cross-section images acquired, and recombined into a 3D reconstruction showing just 3 neurons extending across most of the brain.

Learn More @ Nature

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