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Versatile Synthetic Alternatives to Matrigel for Vascular Toxicity Screening and Stem Cell Expansion

Researchers from University of Wisconsin-Madison have published a new method in Nature Biomedical Engineering for optimizing synthetic cell culture substrates for use in both vascular network growth and stem cell expansion in vitro. Imaging was performed using a Nikon A1R resonant-scanning confocal microscope.

Learn More @ Nature Biomedical Engineering

Acclimatization of Symbiotic Corals to Mesophotic Light Environments Through Wavelength Transformation by Fluorescent Protein Pigments

The symbiotic algae of reef #coral perform photosynthesis, providing nutrients for both organisms. However, new research in Proceedings of the Royal Society B shows that in deeper water corals produce more red fluorescent proteins. The red fluorescent light better penetrates algae-containing tissues than the blue light typically found in deep water.

Learn More @ Proceedings of the Royal Society B

Altering the Threshold of an Excitable Signal Transduction Network Changes Cell Migratory Modes

Research appearing in Nature Cell Biology shows that different cell migratory modes arise from varying threshold levels for the excitation of related signal transduction pathways. Change in cell migratory mode is an important aspect of metastasis.

TIRF imaging of signal transduction and the cytoskeleton was performed using a Nikon Ti-E inverted microscope.

Learn More @ Nature Cell Biology

Optogenetic Protein Clustering Through Fluorescent Protein Tagging and Extension of CRY2

New tool for light-induced protein homo-oligomerization using the CRY2 protein introduced in research published in Nature Communications. Potential applications include investigation and control of rapid signaling dynamics in living systems.

Live-cell imaging was performed with a Nikon A1R resonant-scanning #confocal microscope and fixed-cell imaging with the Nikon N-SIM super-resolution structured illumination system.

Learn More @ Nature Communications

Independent and Stochastic Action of DNA Polymerases in the Replisome

New research in Cell finds that the rate of synthesis for leading and lagging strand DNA polymerases are uncoordinated and can vary up to 10-fold. Furthermore, when DNA polymerase activity is paused, the rate of DNA unwinding by helicase drops by ~80% to allow for recoupling. Imaging was performed using a Nikon TE2000-U with 100x (NA 1.49) TIRF objective.

Learn More @ Cell

RNA Phase Transitions in Repeat Expansion Disorders

New research in Nature shows that nucleotide repeat expansion disorders, such as ALS, require a certain number of repeats before transcripts form foci in the nucleus, with in vitro experiments showing that multivalent base-paring can lead to gelation of RNA.

Imaging was performed using a Nikon Ti-E inverted research microscope with Yokogawa X1 spinning disk.

Learn More @ Nature

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