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Developmental Alterations in Huntington's Disease Neural Cells and Pharmacological Rescue in Cells and Mice

New research in Nature Neuroscience examines the mechanisms underlying neurodegeneration due to Huntington’s disease. Patient-derived induced pluripotent stem cells were used to create neural models of the disease, and RNA-seq applied towards identification of genes with decreased expression. Treatment targeting key dysregulated pathways is demonstrated in mice models. Automated robotic microscopy of iPSC cultures was performed using a Nikon Ti inverted microscope with Perfect Focus.

Learn More @ Nature Neuroscience

2017 Focus On Microscopy

The 2017 Focus On Microscopy conferences are fast approaching! Come find us at Booth 4/5/6/7 and Lecture Room H1/H2 from April 9-12 at the Palais Des Congrès in Bordeaux, France.

We will be holding workshops on imaging with the new Ti2, correlative confocal and SIM imaging, and enhanced confocal imaging. To sign up, please contact us at instruments-info.eu@nikon.com.

Learn More @ Nikon Instruments

Lung Vaso-occlusion in Sickle Cell Disease Mediated by Arteriolar Neutrophil-platelet Microemboli

Researchers at University of Pittsburgh have demonstrated the therapeutic potential of targeting platelet adhesion molecules in reducing the formation of neutrophil-platelet aggregates, which form microemboli in patients with sickle cell disease. Intravital imaging was performed with a Nikon A1R MP multiphoton system and super-resolution SIM using a Nikon N-SIM system. Check out the open-access article in Journal of Clinical Investigation to learn more.

Learn More @ JCI Insight

First Fluorescent Frog Found

The first fluorescent frog has been found! The polka dot tree frog fluoresces blue and green upon excitation by UV light. Researchers are now considering the evolutionary function of fluorescence in this, and perhaps other, frog species.

Learn More @ Nature

The Quest to Crystallize Time

A “time crystal” may sound like a sci-fi/fantasy MacGuffin, but they’re real, and they’re weird…
Where normal crystals exhibit 3D spatial symmetry, time crystal structure is also symmetrical in time. Check out this Nature News and Comment article to learn about the recent creation of time crystals and their implications.

Learn More @ Nature

Super-Resolution and Confocal Seminar

Please join us tomorrow, March 7th for a seminar on Super-Resolution and Confocal Microscopy at the UTHealth Science Center. The seminar will be held in MSB 2.103 from 10:30AM – 12:00PM.

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength

New research in Biophysical Journal identifies differences in Mg2+ and Ca2+ mediated cell adhesion strength between metastatic and non-metastatic cells. Adhesion strength in metastatic cells is more sensitive to Mg2+ and Ca2+ mediated focal adhesion disassembly, whereas non-metastatic cell adhesion is insensitive to these ions. Imaging was performed using a Nikon Ti-S inverted microscope.

Learn More @ Biophysical Journal

Focus On Microscopy Conferences

This year’s Focus On Microscopy conferences (FOM) will be held 9-12 April at the Bordeaux Congress Centre in Bordeaux, France. Come find Nikon at Booth 4/5/6/7 and make sure to check out the newly released Ti2 inverted microscope, featuring an unprecedented 25 mm Field of View! Nikon will also be holding a series of workshops.

FOM is a series of meetings on advanced light microscopy techniques; this year’s topics include confocal, multiphoton, super-resolution, and more.

Learn More @ Nikon Instruments

A Giant Neuron Found Wrapped Around Entire Mouse Brain

Check out this news article in Nature about a new imaging method used to identify a single neuron encircling an entire mouse brain. Researchers believe this technique might help elucidate the mechanisms of consciousness. GFP was used to selectively mark a small number of claustrum neurons, 10,000 cross-section images acquired, and recombined into a 3D reconstruction showing just 3 neurons extending across most of the brain.

Learn More @ Nature

Cryogenic Optical Localization Provides 3D Protein Structure Data with Angstrom Resolution

Optical microscopy with angstrom resolution? New research in Nature Communications details Cryogenic Optical Localization in 3D (COLD), a single molecule localization technique utilizing cryogenic temperatures to manipulate photochemical processes, allowing for orders of magnitude higher numbers of photons to be detected than conventionally possible. Multiple sites on small-to-medium size biomolecules are independently localized.

Learn More @ Nature Methods

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment

New open access research in The American Journal of Human Genetics identifies mutations in INPP5K, encoding inositol polyphosphate-5-phospatase K, impairing phosphatase activity and resulting in altered subcellular localization. The provided data links congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity. Imaging was performed using a Nikon A1R resonant scanning confocal microscope.

Learn More @ The American Journal of Human Genetics

Synthetic Vulnerabilities of Mesenchymal Subpopulations in Pancreatic Cancer

New research in Nature tackles the mechanisms of cancer cell plasticity in a Kras mouse model of pancreatic ductal adenocarcinoma (PDAC), finding that the emergence of Kras-independent escaper populations is associated with de-differentiation and aggressive behavior. Their research points to a potential therapeutic strategy, check out the paper to learn more! Imaging experiments were performed with either a Nikon Ti, Ci, or Ni equipped with A1R-MP multiphoton scanner.

Learn More @ Nature

Big Labs and Tiny Instruments

Learn more about Nikon's new Ti2 and Ts2R microscopes in this recent issue of BioTechniques: The International Journal of Life Science Methods!

This article highlights how the Ti2’s Assist Guide technology simplifies imaging by providing interactive walkthroughs for critical imaging techniques and alerting users to errors, important for training, quality control, and data reproducibility.

Learn More @ BioTechniques

Nikon Instruments Inc. Receives iF Design Award for Superior Product Design

We’re honored that our new Ti2 microscope is receiving the 2017 iF Design Award for superior product design! The ECLIPSE Ti2 Inverted Research Microscope was recognized for its groundbreaking field of view, stability, and usability by the iF International Forum Design. Over 5,575 entries were received from 59 different countries and evaluated by renowned experts.

Learn More @ Nikon Instruments

A Critical Role for p38MAPK Signalling Pathway During Reprogramming of Human Fibroblasts to iPSCs

The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) has become very important in the field of regenerative medicine. New open access research in Scientific Reports explores the role of the p38 MAPK signaling pathway in the creation of iPSCs. Imaging was performed in part using a Nikon A1R laser scanning confocal microscope.

Learn More @ Nature Scientific Reports

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