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Mitotic Progression Following DNA Damage Enables Pattern Recognition Within Micronuclei

Fighting cancer with radiotherapy and chemotherapy relies on DNA double-strand breaks (DSBs) to kill tumour cells. New research in Nature now shows that tumour cell division following DSBs results in the formation of micronuclei, which has a number of important implications for treatment. Imaging was performed in part using a Nikon 80i upright microscope with NIS-Elements software.

Learn More @ Nature

Nikon Turns 100!

On this day in 1917 two of Japan’s leading optical manufacturers merged to form Nippon Kogaku K. K., known today as Nikon. We look forward to serving the imaging community for the next 100 years!

Learn More @ Nikon

Versatile Synthetic Alternatives to Matrigel for Vascular Toxicity Screening and Stem Cell Expansion

Researchers from University of Wisconsin-Madison have published a new method in Nature Biomedical Engineering for optimizing synthetic cell culture substrates for use in both vascular network growth and stem cell expansion in vitro. Imaging was performed using a Nikon A1R resonant-scanning confocal microscope.

Learn More @ Nature Biomedical Engineering

Acclimatization of Symbiotic Corals to Mesophotic Light Environments Through Wavelength Transformation by Fluorescent Protein Pigments

The symbiotic algae of reef #coral perform photosynthesis, providing nutrients for both organisms. However, new research in Proceedings of the Royal Society B shows that in deeper water corals produce more red fluorescent proteins. The red fluorescent light better penetrates algae-containing tissues than the blue light typically found in deep water.

Learn More @ Proceedings of the Royal Society B

Altering the Threshold of an Excitable Signal Transduction Network Changes Cell Migratory Modes

Research appearing in Nature Cell Biology shows that different cell migratory modes arise from varying threshold levels for the excitation of related signal transduction pathways. Change in cell migratory mode is an important aspect of metastasis.

TIRF imaging of signal transduction and the cytoskeleton was performed using a Nikon Ti-E inverted microscope.

Learn More @ Nature Cell Biology

Optogenetic Protein Clustering Through Fluorescent Protein Tagging and Extension of CRY2

New tool for light-induced protein homo-oligomerization using the CRY2 protein introduced in research published in Nature Communications. Potential applications include investigation and control of rapid signaling dynamics in living systems.

Live-cell imaging was performed with a Nikon A1R resonant-scanning #confocal microscope and fixed-cell imaging with the Nikon N-SIM super-resolution structured illumination system.

Learn More @ Nature Communications

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