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Super-Resolution and Confocal Seminar

Please join us tomorrow, March 7th for a seminar on Super-Resolution and Confocal Microscopy at the UTHealth Science Center. The seminar will be held in MSB 2.103 from 10:30AM – 12:00PM.

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength

New research in Biophysical Journal identifies differences in Mg2+ and Ca2+ mediated cell adhesion strength between metastatic and non-metastatic cells. Adhesion strength in metastatic cells is more sensitive to Mg2+ and Ca2+ mediated focal adhesion disassembly, whereas non-metastatic cell adhesion is insensitive to these ions. Imaging was performed using a Nikon Ti-S inverted microscope.

Learn More @ Biophysical Journal

Focus On Microscopy Conferences

This year’s Focus On Microscopy conferences (FOM) will be held 9-12 April at the Bordeaux Congress Centre in Bordeaux, France. Come find Nikon at Booth 4/5/6/7 and make sure to check out the newly released Ti2 inverted microscope, featuring an unprecedented 25 mm Field of View! Nikon will also be holding a series of workshops.

FOM is a series of meetings on advanced light microscopy techniques; this year’s topics include confocal, multiphoton, super-resolution, and more.

Learn More @ Nikon Instruments

A Giant Neuron Found Wrapped Around Entire Mouse Brain

Check out this news article in Nature about a new imaging method used to identify a single neuron encircling an entire mouse brain. Researchers believe this technique might help elucidate the mechanisms of consciousness. GFP was used to selectively mark a small number of claustrum neurons, 10,000 cross-section images acquired, and recombined into a 3D reconstruction showing just 3 neurons extending across most of the brain.

Learn More @ Nature

Cryogenic Optical Localization Provides 3D Protein Structure Data with Angstrom Resolution

Optical microscopy with angstrom resolution? New research in Nature Communications details Cryogenic Optical Localization in 3D (COLD), a single molecule localization technique utilizing cryogenic temperatures to manipulate photochemical processes, allowing for orders of magnitude higher numbers of photons to be detected than conventionally possible. Multiple sites on small-to-medium size biomolecules are independently localized.

Learn More @ Nature Methods

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment

New open access research in The American Journal of Human Genetics identifies mutations in INPP5K, encoding inositol polyphosphate-5-phospatase K, impairing phosphatase activity and resulting in altered subcellular localization. The provided data links congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity. Imaging was performed using a Nikon A1R resonant scanning confocal microscope.

Learn More @ The American Journal of Human Genetics

Synthetic Vulnerabilities of Mesenchymal Subpopulations in Pancreatic Cancer

New research in Nature tackles the mechanisms of cancer cell plasticity in a Kras mouse model of pancreatic ductal adenocarcinoma (PDAC), finding that the emergence of Kras-independent escaper populations is associated with de-differentiation and aggressive behavior. Their research points to a potential therapeutic strategy, check out the paper to learn more! Imaging experiments were performed with either a Nikon Ti, Ci, or Ni equipped with A1R-MP multiphoton scanner.

Learn More @ Nature

Big Labs and Tiny Instruments

Learn more about Nikon's new Ti2 and Ts2R microscopes in this recent issue of BioTechniques: The International Journal of Life Science Methods!

This article highlights how the Ti2’s Assist Guide technology simplifies imaging by providing interactive walkthroughs for critical imaging techniques and alerting users to errors, important for training, quality control, and data reproducibility.

Learn More @ BioTechniques

Nikon Instruments Inc. Receives iF Design Award for Superior Product Design

We’re honored that our new Ti2 microscope is receiving the 2017 iF Design Award for superior product design! The ECLIPSE Ti2 Inverted Research Microscope was recognized for its groundbreaking field of view, stability, and usability by the iF International Forum Design. Over 5,575 entries were received from 59 different countries and evaluated by renowned experts.

Learn More @ Nikon Instruments

A Critical Role for p38MAPK Signalling Pathway During Reprogramming of Human Fibroblasts to iPSCs

The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) has become very important in the field of regenerative medicine. New open access research in Scientific Reports explores the role of the p38 MAPK signaling pathway in the creation of iPSCs. Imaging was performed in part using a Nikon A1R laser scanning confocal microscope.

Learn More @ Nature Scientific Reports

Biophysical Society Annual Meeting

The 61st Annual Meeting of the Biophysical Society starts this coming Saturday, February 11th at the Ernest Morial Convention Center in beautiful New Orleans! Come find us at Booth 431 and see our latest Eclipse Ti2 inverted microscope and other imaging solutions. Also make sure to get your own Ti2 TICO brick model!

Learn More @ Nikon Instruments

Functionally and Morphologically Damaged Mitochondria Observed in Auditory Cells Under Senescence-Inducing Stress

What role do mitochondria play in the premature senescence of auditory cells? New research in npj Aging and Mechanisms of Disease finds that short H2O2 treatment of auditory cells leads to a decrease in mitochondrial membrane potential and fusion/fission imbalance, providing evidence for the interdependence of these factors in premature senescence. Super-resolution imaging of mitochondria was performed using a Nikon N-SIM structured illumination system.

Learn More @ npj Aging and Mechanisms of Disease

Elevated-Temperature-Induced Acceleration of PACT Clearing Process of Mouse Brain Tissue

Tissue optical clearing techniques have become an important method for neural imaging. New research in Scientific Reports details an optimized protocol for the Passive Clarity Technique (PACT), finding 42-47oC incubation is optimal for producing faster clearing while preserving fluorescence. Imaging for this study was performed in part using a Nikon A1R-MP multiphoton system with 16x water dipping objective (NA=0.8).

Learn More @ Nature Scientific Reports

Physicists Doubt Bold Report of Metallic Hydrogen

Did two physicists just succeed in creating metallic hydrogen? Researchers at Harvard University just published a report in Science presenting evidence of this achievement. Polished diamonds were used to apply 495 GPa of pressure (higher than the pressure at the center of the Earth) to hydrogen gas, seemingly resulting in a new metallic form of hydrogen that has yet to be observed. If true, this material could have an array of potential applications, including as a room temperature super conductor.

Learn More @ Nature

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