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Iterative Expansion Microscopy

Check out new iterative Expansion Microscopy published in Nature Methods. Samples are physically magnified ~20x, compared to previous factor of ~4.5x. This new method is validated for visualization of synaptic proteins and the structure of dendritic spines. Imaging was performed using a Nikon Ti-E inverted microscope with 40x 1.15 NA water immersion objective.

Learn More @ Nature Methods

Anchored But Not Internalized: Shape Dependent Endocytosis of Nanodiamond

New research in Scientific Reports examines how morphology affects the endocytosis of nanoparticles, a critical step for applications ranging from intracellular sensing to drug delivery. They found that round nanodiamond is endocytosed to a greater degree than “prickly”-shaped nanodiamond. Super-resolution imaging was performed using a Nikon N-SIM structured illumination system.

Learn More @ Nature Scientific Reports

Allen Cell Explorer

Check out the newly released Allen Cell Explorer, a library of thousands of induced pluripotent #stemcell images created by the Allen Institute for Cell Science. Future plans include the application of machine learning to predict the position and morphology of cell components based off other markers.

Learn More @ Allen Cell Explorer

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