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August 24, 2017, via Science Advances
Did you know that macrophages sometimes release live pathogens in a process known as vomocytosis? Researchers have now identified ERK5 as the first known host-signaling regulator of this process. A Nikon Ti-E inverted microscope was used for imaging.
August 24, 2017, via Nature Scientific Reports
New research explores optical micro-printing tech for fabrication of microscaffold arrays for 3D cell culture. Imaging was performed with a Nikon C2 confocal microscope.
August 24, 2017, via Optical Society of America
Computational super-resolution inverse diffraction phase retrieval may sound like a mouthful, but is a big step forward in lensless computational microscopy.
August 23, 2017, via Science Advances
New research in Science Advances demonstrates how impaired mitochondrial gene expression can trigger adult-onset obesity. Imaging was performed using a Nikon Ti inverted microscope.
August 23, 2017, via Molecular Therapy
New research uses the AAV-PHP.B viral platform for non-invasive and long-lasting expression of GBA1 as a therapeutic gene for treatment of various synucleinopathies. Imaging was performed with a Nikon E-600 upright microscope.
August 22, 2017, via Nature Communications
Did you know that bacteria can kill and feed upon other bacteria? New research in Scientific Reports shows that B. subtilis can deliver toxin to B. megaterium while also extracting nutrients. Imaging was performed using a Nikon Ti inverted microscope.
August 17, 2017, via Howard Hughes Medical Institute
Congrats to this year’s Gilliam Fellows! Howard Hughes Medical Institute awards Gilliam Fellowships to promote diversity and inclusion in the sciences.
August 16, 2017, via PNAS
New research in PNAS provides a “how-to” guide to growing hair-producing organoids from dissociated skin cells.
August 16, 2017, via Nature Scientific Reports
A new form of quantitative phase imaging allows greater resolution than previous by using low coherence illumination.
August 15, 2017, via Science Advances
Membrane localization of acetylated CNK1 is found to mediate a positive feedback on RAF/ERK signaling in new research published in Science Advances. Imaging was performed using a Nikon TS100 inverted microscope.
August 14, 2017, via bioRxiv
Exciting advancements in Expansion Microscopy (ExM) detailed in bioRxiv pre-print. This new version of ExM increases one-step expansion factor of the technique from 4x to 10x, providing ~30 nm xy resolution.
August 11, 2017, via Nature Scientific Reports
Research in Scientific Reports improves the ability of mesenchymal stem cells to home towards sites of inflammation via overexpression of CD44. Imaging was performed in part using a Nikon A1R confocal system.
August 11, 2017, via Molecular Cell
Myc has been identified as a key regulator of nuclear architecture during B Cell activation. Single molecule imaging for this study was performed using a Nikon N-STORM system.
August 10, 2017, via Science Daily
Could new ‘buckyswitch’ fluorophores be the answer to sample preparation for STORM microscopy? This new probe is about 10x brighter than synthetic dye and demonstrated with sub-1 nm localization precision.
August 09, 2017, via Current Biology
A new and exceptionally preserved armored dinosaur species was found in Alberta. This dino had a highly camouflaged coloration, indicative of strong predatory pressure. Cross-polarized light photography was performed using a Nikon D800 dSLR camera.
August 07, 2017, via Science Advances
New CRISPR research has identified a Cas9 conformational checkpoint between DNA binding and cleavage. Single molecule FRET was performed using a Nikon Ti-E inverted microscope with TIRF illumination.
August 07, 2017, via Nature Scientific Reports
The first micro-computed tomography 3D model of the cardiac conduction system in a living human heart was published in Scientific Reports. This will allow for more sophisticated models of heart function, with implications for heart surgery and drug discovery. MicroCT scanning was performed using both the Nikon Metris XTEK 320 kV and XTEK XTH 225 kV systems.
August 04, 2017, via Cell Stem Cell
Research in Cell Stem Cell describes a 3D pluripotent stem cell culture technique for generating human brain organoids resembling the MGE and cortical domains. Movie of neuron migration below. Calcium imaging was performed using a Nikon TS-100, electrophysiology in conjunction with a Nikon FN-1, and imaging of fixed brain slices using a Nikon C1 confocal microscope.
August 03, 2017, via Cell Chemical Biology
We’ve all heard about foodborne illnesses caused by E. coli and Listeria sp. Old methods for food surveillance may require several days to identify contamination, but new research provides a quick bio-orthogonal method for fluorescent labeling of bacteria. Imaging was performed in part using a Nikon Ti inverted microscope.
August 03, 2017, via Nature Cell Biology
New Elastic Resonator Interference Stress Microscopy (ERISM) allows detection of vertical stresses via deformation of an elastic substrate beneath the cells. The ERISM system was configured on a Nikon Ti-S inverted microscope.
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