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High Resolution 3-Dimensional Imaging of the Human Cardiac Conduction System From Microanatomy to Mathematical Modeling

The first micro-computed tomography 3D model of the cardiac conduction system in a living human heart was published in Scientific Reports. This will allow for more sophisticated models of heart function, with implications for heart surgery and drug discovery. MicroCT scanning was performed using both the Nikon Metris XTEK 320 kV and XTEK XTH 225 kV systems.

Learn More @ Nature Scientific Reports

Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration

Research in Cell Stem Cell describes a 3D pluripotent stem cell culture technique for generating human brain organoids resembling the MGE and cortical domains. Movie of neuron migration below. Calcium imaging was performed using a Nikon TS-100, electrophysiology in conjunction with a Nikon FN-1, and imaging of fixed brain slices using a Nikon C1 confocal microscope.

Learn More @ Cell Stem Cell

Rapid Screening and Identification of Living Pathogenic Organisms via Optimized Bioorthogonal Non-canonical Amino Acid Tagging

We’ve all heard about foodborne illnesses caused by E. coli and Listeria sp. Old methods for food surveillance may require several days to identify contamination, but new research provides a quick bio-orthogonal method for fluorescent labeling of bacteria. Imaging was performed in part using a Nikon Ti inverted microscope.

Learn More @ Cell Chemical Biology

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Optical µ-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture

Computational Super-Resolution Phase Retrieval From Multiple Phase-Coded Diffraction Patterns: Simulation Study and Experiments

Vomocytosis of Live Pathogens From Macrophages Is Regulated by the Atypical MAP Kinase ERK5

Adult-onset Obesity is Triggered by Impaired Mitochondrial Gene Expression

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

Interspecies Nutrient Extraction and Toxin Delivery Between Bacteria

HHMI Awards 39 Gilliam Fellowships to Support Diversity in Science

Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells

High-Resolution Transport-of-Intensity Quantitative Phase Microscopy With Annular Illumination

Membrane Localization of Acetylated CNK1 Mediates a Positive Feedback on RAF/ERK Signaling

X10 Expansion Microscopy Enables 25 nm Resolution on Conventional Microscopes

Hyaluronic Acid Coatings as a Simple and Efficient Approach to Improve MSC Homing Toward the Site of Inflammation

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

Field of Microscopy with Nanoparticle 'Buckyswitch'

An Exceptionally Preserved Three-Dimensional Armored Dinosaur Reveals Insights into Coloration and Cretaceous Predator-Prey Dynamics

A Conformational Checkpoint Between DNA Binding and Cleavage by CRISPR-Cas9

High Resolution 3-Dimensional Imaging of the Human Cardiac Conduction System From Microanatomy to Mathematical Modeling

Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration

Rapid Screening and Identification of Living Pathogenic Organisms via Optimized Bioorthogonal Non-canonical Amino Acid Tagging

Long-term Imaging of Cellular Forces with High Precision by Elastic Resonator Interference Stress Microscopy