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April 18, 2017, via Crosstalk
Chances are you’ve heard of Pokemon, but probably not the Mallorcan Midwife toad. In response, researchers created the Phylo trading card game, where players create and populate ecosystems while trying to avoid fires and oil spills. What would your favorite Phylo card be?
April 18, 2017, via Cell Crosstalk
New blog post in Cell discusses state of superresolution microscopy, including recent applications and with a link to free collection of select articles.
April 17, 2017, via Nature Methods
Check out new iterative Expansion Microscopy published in Nature Methods. Samples are physically magnified ~20x, compared to previous factor of ~4.5x. This new method is validated for visualization of synaptic proteins and the structure of dendritic spines. Imaging was performed using a Nikon Ti-E inverted microscope with 40x 1.15 NA water immersion objective.
April 14, 2017, via Nature Scientific Reports
New research in Scientific Reports examines how morphology affects the endocytosis of nanoparticles, a critical step for applications ranging from intracellular sensing to drug delivery. They found that round nanodiamond is endocytosed to a greater degree than “prickly”-shaped nanodiamond. Super-resolution imaging was performed using a Nikon N-SIM structured illumination system.
April 06, 2017, via Nature Scientific Reports
New open access research in Scientific Reports demonstrates 3D bioprinting of cartilage tissue using induced pluripotent stem cells. Applications include treatment of cartilage lesions, which can progress into secondary osteoarthritis. Imaging was performed in part with a Nikon C2 confocal system.
April 05, 2017, via Nikon Small World
The deadline to enter the Nikon Small World Photomicrography and Video Competitions is approaching. Submit your images and movies taken through the light microscope by April 30th for a chance to win a trip to Nikon’s headquarters in Japan.
April 05, 2017, via Allen Cell Explorer
Check out the newly released Allen Cell Explorer, a library of thousands of induced pluripotent #stemcell images created by the Allen Institute for Cell Science. Future plans include the application of machine learning to predict the position and morphology of cell components based off other markers.
March 31, 2017, via Cell
New open access research in Stem Cell Reports utilized induced pluripotent stem (iPSC) models of amyotrophic lateral sclerosis to identify pathways dysregulated by mutant SOD1 in human motor neurons, finding that ERK and JNK signaling are key in neurodegeneration. Electrophysiology experiments were performed on a Nikon Ti-E inverted microscope.
March 24, 2017, via Nature
Researchers at UCSF have provided the first direct evidence for substantial platelet biogenesis in the lungs in a new article published in Nature. A Nikon A1R MP multiphoton microscope was used to visualize lung microcirculation in mice, showing large numbers of megakaryocytes dynamically releasing platelets. Approximately half of platelet production was found to occur in the lungs in their model.
March 23, 2017, via Nikon Instruments
If you’re looking to join a company with a dynamic vision for the future, set your sights on a challenging career with Nikon. Nikon USA is currently looking for a Bioscience Consignment & Trade Show Administrator! Key responsibilities of this position include coordinating equipment for tradeshows, workshops, and more. This is a great opportunity for non-specialists with strong organizational skills and who are available to travel to learn about optical microscopy and the medical device industry. To learn more and apply click below!
March 22, 2017, via Nature Neuroscience
New research in Nature Neuroscience examines the mechanisms underlying neurodegeneration due to Huntington’s disease. Patient-derived induced pluripotent stem cells were used to create neural models of the disease, and RNA-seq applied towards identification of genes with decreased expression. Treatment targeting key dysregulated pathways is demonstrated in mice models. Automated robotic microscopy of iPSC cultures was performed using a Nikon Ti inverted microscope with Perfect Focus.
March 21, 2017, via Nikon Instruments
The 2017 Focus On Microscopy conferences are fast approaching! Come find us at Booth 4/5/6/7 and Lecture Room H1/H2 from April 9-12 at the Palais Des Congrès in Bordeaux, France.
We will be holding workshops on imaging with the new Ti2, correlative confocal and SIM imaging, and enhanced confocal imaging. To sign up, please contact us at instruments-info.eu@nikon.com.
March 19, 2017, via JCI Insight
Researchers at University of Pittsburgh have demonstrated the therapeutic potential of targeting platelet adhesion molecules in reducing the formation of neutrophil-platelet aggregates, which form microemboli in patients with sickle cell disease. Intravital imaging was performed with a Nikon A1R MP multiphoton system and super-resolution SIM using a Nikon N-SIM system. Check out the open-access article in Journal of Clinical Investigation to learn more.
March 15, 2017, via Nature
The first fluorescent frog has been found! The polka dot tree frog fluoresces blue and green upon excitation by UV light. Researchers are now considering the evolutionary function of fluorescence in this, and perhaps other, frog species.
March 10, 2017, via Google Research Blog
Is Google pioneering the future of digital pathology? Researchers at the tech giant report the use of deep learning approaches for accurate and automatic detection of tumors from microscopy images.
March 08, 2017, via Nature
A “time crystal” may sound like a sci-fi/fantasy MacGuffin, but they’re real, and they’re weird…
Where normal crystals exhibit 3D spatial symmetry, time crystal structure is also symmetrical in time. Check out this Nature News and Comment article to learn about the recent creation of time crystals and their implications.
March 06, 2017
Please join us tomorrow, March 7th for a seminar on Super-Resolution and Confocal Microscopy at the UTHealth Science Center. The seminar will be held in MSB 2.103 from 10:30AM – 12:00PM.
March 03, 2017, via Biophysical Journal
New research in Biophysical Journal identifies differences in Mg2+ and Ca2+ mediated cell adhesion strength between metastatic and non-metastatic cells. Adhesion strength in metastatic cells is more sensitive to Mg2+ and Ca2+ mediated focal adhesion disassembly, whereas non-metastatic cell adhesion is insensitive to these ions. Imaging was performed using a Nikon Ti-S inverted microscope.
March 01, 2017, via Nikon Instruments
This year’s Focus On Microscopy conferences (FOM) will be held 9-12 April at the Bordeaux Congress Centre in Bordeaux, France. Come find Nikon at Booth 4/5/6/7 and make sure to check out the newly released Ti2 inverted microscope, featuring an unprecedented 25 mm Field of View! Nikon will also be holding a series of workshops.
FOM is a series of meetings on advanced light microscopy techniques; this year’s topics include confocal, multiphoton, super-resolution, and more.
March 01, 2017, via Nature
Check out this news article in Nature about a new imaging method used to identify a single neuron encircling an entire mouse brain. Researchers believe this technique might help elucidate the mechanisms of consciousness. GFP was used to selectively mark a small number of claustrum neurons, 10,000 cross-section images acquired, and recombined into a 3D reconstruction showing just 3 neurons extending across most of the brain.
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