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Cryogenic Optical Localization Provides 3D Protein Structure Data with Angstrom Resolution

Optical microscopy with angstrom resolution? New research in Nature Communications details Cryogenic Optical Localization in 3D (COLD), a single molecule localization technique utilizing cryogenic temperatures to manipulate photochemical processes, allowing for orders of magnitude higher numbers of photons to be detected than conventionally possible. Multiple sites on small-to-medium size biomolecules are independently localized.

Learn More @ Nature Methods

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment

New open access research in The American Journal of Human Genetics identifies mutations in INPP5K, encoding inositol polyphosphate-5-phospatase K, impairing phosphatase activity and resulting in altered subcellular localization. The provided data links congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity. Imaging was performed using a Nikon A1R resonant scanning confocal microscope.

Learn More @ The American Journal of Human Genetics

Synthetic Vulnerabilities of Mesenchymal Subpopulations in Pancreatic Cancer

New research in Nature tackles the mechanisms of cancer cell plasticity in a Kras mouse model of pancreatic ductal adenocarcinoma (PDAC), finding that the emergence of Kras-independent escaper populations is associated with de-differentiation and aggressive behavior. Their research points to a potential therapeutic strategy, check out the paper to learn more! Imaging experiments were performed with either a Nikon Ti, Ci, or Ni equipped with A1R-MP multiphoton scanner.

Learn More @ Nature

Big Labs and Tiny Instruments

Learn more about Nikon's new Ti2 and Ts2R microscopes in this recent issue of BioTechniques: The International Journal of Life Science Methods!

This article highlights how the Ti2’s Assist Guide technology simplifies imaging by providing interactive walkthroughs for critical imaging techniques and alerting users to errors, important for training, quality control, and data reproducibility.

Learn More @ BioTechniques

Nikon Instruments Inc. Receives iF Design Award for Superior Product Design

We’re honored that our new Ti2 microscope is receiving the 2017 iF Design Award for superior product design! The ECLIPSE Ti2 Inverted Research Microscope was recognized for its groundbreaking field of view, stability, and usability by the iF International Forum Design. Over 5,575 entries were received from 59 different countries and evaluated by renowned experts.

Learn More @ Nikon Instruments

A Critical Role for p38MAPK Signalling Pathway During Reprogramming of Human Fibroblasts to iPSCs

The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) has become very important in the field of regenerative medicine. New open access research in Scientific Reports explores the role of the p38 MAPK signaling pathway in the creation of iPSCs. Imaging was performed in part using a Nikon A1R laser scanning confocal microscope.

Learn More @ Nature Scientific Reports

Biophysical Society Annual Meeting

The 61st Annual Meeting of the Biophysical Society starts this coming Saturday, February 11th at the Ernest Morial Convention Center in beautiful New Orleans! Come find us at Booth 431 and see our latest Eclipse Ti2 inverted microscope and other imaging solutions. Also make sure to get your own Ti2 TICO brick model!

Learn More @ Nikon Instruments

Functionally and Morphologically Damaged Mitochondria Observed in Auditory Cells Under Senescence-Inducing Stress

What role do mitochondria play in the premature senescence of auditory cells? New research in npj Aging and Mechanisms of Disease finds that short H2O2 treatment of auditory cells leads to a decrease in mitochondrial membrane potential and fusion/fission imbalance, providing evidence for the interdependence of these factors in premature senescence. Super-resolution imaging of mitochondria was performed using a Nikon N-SIM structured illumination system.

Learn More @ npj Aging and Mechanisms of Disease

Elevated-Temperature-Induced Acceleration of PACT Clearing Process of Mouse Brain Tissue

Tissue optical clearing techniques have become an important method for neural imaging. New research in Scientific Reports details an optimized protocol for the Passive Clarity Technique (PACT), finding 42-47oC incubation is optimal for producing faster clearing while preserving fluorescence. Imaging for this study was performed in part using a Nikon A1R-MP multiphoton system with 16x water dipping objective (NA=0.8).

Learn More @ Nature Scientific Reports

Physicists Doubt Bold Report of Metallic Hydrogen

Did two physicists just succeed in creating metallic hydrogen? Researchers at Harvard University just published a report in Science presenting evidence of this achievement. Polished diamonds were used to apply 495 GPa of pressure (higher than the pressure at the center of the Earth) to hydrogen gas, seemingly resulting in a new metallic form of hydrogen that has yet to be observed. If true, this material could have an array of potential applications, including as a room temperature super conductor.

Learn More @ Nature

The Spatiotemporal Limits of Developmental Erk Signaling

Researchers at Princeton University have published a new article in Developmental Cell demonstrating optogenetic control of Erk signaling in vivo using patterned illumination from a Digital Micro-mirror Device (DMD). They found that development is very robust to ectopic Erk signaling except from 1-4 hours post-fertilization. Fluorescence imaging was performed using both a Nikon A1-R resonant scanning confocal microscope and a Nikon Ti-E with spinning disk and DMD for optogenetics experiments.

Learn More @ Developmental Cell

Multiplexing PKA and ERK1&2 Kinases FRET Biosensors in Living Cells Using Single Excitation Wavelength Dual Colour FLIM

An open-access research article in Scientific Reports details a new approach to multiplexing FRET biosensors for kinase activity (PKA and ERK1&2) in living cells using only a single excitation wavelength for simultaneous dual-color FLIM. LSSmOrange-mKate2 and mTFP1-ShadowG were the FRET pairs chosen, both donors excited by 440 nm light and all probes being spectrally separate. Sensitized emission measurements were made using a Nikon Ti-E inverted microscope with Nikon DS-Qi2 sCMOS camera.

Learn More @ Nature Scientific Reports

Nikon Small World Call for Entries

Many of you are likely familiar with our annual Nikon Small World photomicrography competition, but this year is extra special…

In celebration of Nikon’s 100th anniversary the Small World grand prizewinners will receive $3000 and an all-inclusive trip to Japan, joining us as our special guests at the Nikon Worldwide Headquarters. The lucky winners (and their lucky companions) will also receive a private tour of Nikon’s glass and lens manufacturing facilities. Learn more and submit your winning image today!

Learn More @ Nikon Small World

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