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Robotic Microscopy with the Nikon Ti2 for High-Content Analysis Applications

Check out our new application note in Nature Methods discussing how the Nikon Ti2 inverted research microscope is ideally suited to high content imaging applications. The unprecedented 25 mm field of view of the Ti2 (camera port) provides about a two-fold improvement in imaging area over its predecessor, drastically increasing system throughput and speeding up discovery.

Learn More @ Nature Methods

Researchers Put Mouse Embryos in Suspended Animation

Researchers from UCSF and the University of Illinois at Urbana-Champaign have succeeded in pausing the development of mouse blastocysts for up to one month via inhibition of the mTOR protein. Briefly paused embryos retained the ability to develop normally. This strategy also worked on cultured embryonic stem cells, inducing a pluripotent state that can last for weeks in vivo. Their research has implications in a variety of fields, including ageing, cancer, assisted reproduction, and more.

Learn More @ Medical Xpress

Adaptive Light-Sheet Microscopy for Long-Term, High-Resolution Imaging in Living Organisms

New research published in Nature Biotechnology details a method for optimizing spatial resolution during acquisition of light sheet microscopy data. An automated program corrects for mismatches between the plane of light sheet illumination and that imaged by the detection objective in real time, demonstrated by imaging of entire zebrafish and fly embryos. Imaging was performed using a Nikon 16x water-dipping objective.

Learn More @ Nature Biotechnology

Lasers + Anti-Lasers: Marriage Opens Door to Development of Single Device with Exceptional Range of Optical Capabilities

Lasers and… anti-lasers? Researchers at Lawrence Berkeley National Laboratory have constructed a laser that also acts as an anti-laser. A laser emits coherent light - anti-lasers absorb coherent light. A single device that does both may seem paradoxical, but the authors believe the technology may be used to make high sensitivity light detectors, or even photonic integrated circuits. To learn more check out the article.

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See More Than Before with Nikon's Newest Inverted Microscope System

Introducing Nikon's latest imaging innovation- the Eclipse Ti2 Inverted Microscope System. The Ti2 raises the bar for core imaging capability, delivering an unprecedented 25mm field of view, as well as improved stability and usability. To learn more, visit and stop by Nikon's booth at the upcoming Society for Neuroscience Annual Meeting (Nov. 13-16).

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Super-Resolution Imaging of Fluorescently Labeled, Endogenous RNA Polymerase II in Living Cells with CRISPR/Cas9-mediated Gene Editing

Researchers at the Massachusetts Institute of Technology (MIT) have demonstrated super-resolution localization microscopy imaging of endogenous RNA Polymerase II in living cells. Labeling was performed using CRISPR/Cas9-mediated gene editing to add the photoconvertable fluorescent protein Dendra2. This method can in principle be used to label transcription factors for live cell super-resolution as well. Imaging was performed on a Nikon Ti inverted research microscope system with Perfect Focus. Check out the open access Scientific Reports article to learn more.

Learn More @ Nature Scientific Reports

Labeling Cellular Structures in vivo Using Confined Primed Conversion of Photoconvertible Fluorescent Proteins

Researchers at ETH Zürich have published a new method in Nature Protocols for axially confined photoconversion of the fluorescent protein Dendra2 in single cells – demonstrating the concept in developing zebrafish embryos. This method uses a specialized filter plate and the process of ‘primed conversion’ to convert Dendra2 to a red emitting form using 488 nm and 730 nm beams that intersect only at a common focal point.

Learn More @ Nature Protocols

Super-Resolution Dipole Orientation Mapping via Polarization Demodulation

A new open-access research article in the journal Light: Science & Applications details a new Fluorescence Polarization Microscope (FPM) design for super-resolution imaging of the dipole orientations of overlapping single fluorophores in sub-diffraction limited volumes. Using this new technique, they’ve demonstrated that the dipole of actin monomers is perpendicular to the actin filament, and radially distributed in septin complexes in live yeast cells. Imaging was performed on a Nikon Ti-E motorized inverted research microscope.

Learn More @ Light: Science & Applications

Bright Photoactivatable Fluorophores for Single-Molecule Imaging

Researchers at the Janelia Research Campus have developed new photoactivatable dyes for improved live cell single-particle tracking and localization microscopy experiments. The new photoactivatable dyes are derived from existing Janelia Fluor (JF) dyes - known for their increased brightness, photostability, small size, and cell permeability. To learn more, check out the article in Nature Methods.

Learn More @ Nature Methods

Microscopic Fish Face Takes First Place in 2016 Nikon Small World Competition

Nikon Instruments Inc. today announced the winners of the 42nd annual Nikon Small World Photomicrography Competition, awarding first place to Oscar Ruiz, Ph.D. for his microscopic view of the facial development of a four-day-old zebrafish embryo. Fittingly, Nikon unveiled Dr. Ruiz’s zebrafish “selfie” win first on Instagram this morning, giving followers the first look at the winning images. The full winner gallery can now also be viewed on

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Microenvironment Complexity and Matrix Stiffness Regulate Breast Cancer Cell Activity in a 3D in vitro Model

A new open access article in Scientific Reports details the role of extracellular matrix (ECM) stiffness in regulating breast cancer cell activity by testing cell growth on a variety of 2D and 3D substrates. Researchers found that the highest proliferation rates occurred in the softest 3D hydrogels tested – providing more evidence for the need of 3D culture systems recapitulating the native microenvironment in order to reveal disease-relevant phenotypes. Gels were imaged using a Nikon Eclipse Ni-U upright research microscope.

Learn More @ Nature Scientific Reports

Quantum-dot Solar Windows Evolve with 'Doctor-blade' Spreading

Many people in the microscopy world are familiar with quantum dots – semiconductor nanocrystals with well-defined light emitting properties – as fluorescent labels. Researchers at Los Alamos National Laboratory have demonstrated how quantum dot-based solar panels can be scaled up for practical use, large enough to be used as a building window when used in luminescent solar concentrators (LSC). Quantum dots in LSCs absorb photons and emit light at a lower energy, guided by total internal reflection to the edges of the device, where they are collected by photovoltaic cells.

Learn More @ PHYS.ORG

Scientists Bioprint Tubular 3-D Renal Architecture that Recapitulates Functions of the Kidney

A team of researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard realized a major milestone in 3D bioprinting with the construction of a working proximal tubule – a key component of kidney nephrons – made of human epithelial cells. They hope to use these engineered tubules as models of human kidney function, providing a highly relevant system for pre-clinical drug response testing. 

Learn More @ Medical Xpress

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